California Immunization Registry 
Data Exchange Resources

Resources for sites that submit immunization data to CAIR2 from their electronic health record (EHR) systems. 

HL7 VXU Implementation Guide and Test Plan:

• CAIR2 HL7 v2.5.1 VXU Implementation Guide 
• CAIR2 Test Plan for HL7 VXU Submission to CAIR2

HL7 Bidirectional Implementation Guide and Test Plan:

• CAIR2 HL7 v2.5.1 Bi-Directional (QBP/RSP) Implementation Guide
• CAIR2 Bi-directional Data Exchange (BiDX) Test Plan

HL7 Acknowledgement Error Guide:

• CAIR2 IIS HL7 ACK ERROR GUIDE ACK / NAK MESSAGE REFERENCE

For data exchange questions and support, please email CAIRDataExchange@cdph.ca.gov.